The concept
The issuing bank, or issuer, is the buyer's bank. It has the final word: the acquirer forwards the transaction, the card network routes it, and the issuer responds approved or declined in a fraction of a second.
Understanding this changes the diagnosis of a low approval rate. When the decline comes from the issuer, the problem is rarely in your checkout. It's in the transaction profile as the buyer's bank sees it: a currency unfamiliar to their history, a processing country different from the card's country, an out-of-pattern ticket, or an unrecognizable soft descriptor.
How it shows up in practice
You sell courses internationally and notice a pattern of refusals always happens with cards from the same bank. You study the transaction as that bank sees it, change your soft descriptor to be clearer, test offering the buyer's local currency instead of US dollar, test indicating the correct country of the transaction. Some refusals start to go through.
Users spend most of their time on other sites. This means that users prefer your site to work the same way as all the other sites they already know.
The buyer's bank has the final word: it approves or refuses in a fraction of a second. When refusal rate is high, the problem rarely sits in your checkout, it sits in how the issuer sees the transaction profile. Strange currency, country different from card, ticket outside the pattern, these are the variables you control.